ESAT-6-ELISpot and interferon γ in the diagnosis of pleural tuberculosis
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چکیده
منابع مشابه
IFN-γ and IL-2 Responses to Recombinant AlaDH against ESAT-6/CFP-10 Fusion Antigens in the Diagnosis of Latent versus Active Tuberculosis Infection
Background: Discriminating latent tuberculosis infection (LTBI) from active TBI may be challenging. The objective of this study was to produce the recombinant L-alanine dehydrogenase (AlaDH) antigen and evaluate individuals with LTBI, those with active TBI, and uninfected individuals by enzyme-linked immunospot assay (ELISPOT) in order to distinguish LTBI from active TBI.Methods: This explorato...
متن کاملEarly Diagnosis of Tuberculosis-Associated IgA Nephropathy with ESAT-6.
IgA nephropathy (IgAN) is the most common cause of primary renal diseases worldwide, and the early secreted antigenic target of 6 (ESAT-6) which was secreted by Mycobacterium tuberculosis (MTB) may be involved in the development and progression of IgAN. This study aimed to investigate the role of ESAT-6 for early diagnosis of IgAN caused by MTB infection. From 2011 to 2014, 21 patients with ren...
متن کاملInterferon-γ release assays for diagnosis of active pleural tuberculosis: a developing world perspective.
to that presented in our article, no such synergy is apparent. Again, given the limited sample size and specific context of our analysis, no definitive conclusion can be drawn from these results, but it is possible that dog/endotoxin may synergise more powerfully with indoor air pollutants, relative to other exposures. If so, it may be important to understand the biology that underlies this eff...
متن کاملUse of Pleural Fluid Interferon-gamma Enzyme-linked Immunospot Assay in the Diagnosis of Pleural Tuberculosis.
AIM to evaluate the diagnostic value of an interferon-gamma release assay (IGRA) with enzyme-linked immunospot (ELISPOT) method, T-SPOT.TB, in the diagnosis of pleural TB using pleural fluid mononuclear cells (PFMC). METHODS forty-eight subjects, presumed to have pleural TB with exudative pleural effusion by Light's criteria, dominated by mononuclear cells, had their pleural fluid specimen te...
متن کاملDiagnosis of tuberculosis infection using interferon-γ-based assays.
Interferon-γ-based assays, collectively known as IFN-γ release assays (IGRAs), have emerged as a reliable alternative to the old tuberculin skin test (TST) for the immunodiagnosis of tuberculosis (TB) infection. The 2 commercially available tests, the enzyme-linked immunosorbent assay (ELISA), QuantiFERON-TB Gold Intube (QFT-IT), and the enzyme-linked immunospot assay (ELISPOT), T-SPOT.TB, are ...
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ژورنال
عنوان ژورنال: Egyptian Journal of Chest Diseases and Tuberculosis
سال: 2012
ISSN: 0422-7638
DOI: 10.1016/j.ejcdt.2012.10.012